KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Post-translational modifications:
Phosphorylation increases by IL-6.
Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-231 by either caspase-3, caspas-6 or caspase-7.
O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residue.
Similarity:
Belongs to the intermediate filament family.
SWISS:
P05783
Gene ID:
3875
Database links:
Entrez Gene: 50696 Cow
Entrez Gene: 3875 Human
Entrez Gene: 16668 Mouse
Entrez Gene: 294853 Rat
Omim: 29670 Human
SwissProt: P05783 Human
SwissProt: P05784 Mouse
SwissProt: Q5BJY9 Rat
Unigene: 406013 Human
Unigene: 22479 Mouse
Unigene: 103924 Rat
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