Mouse Anti-human CD273 (B7-DC, PD-L2) antibody

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PD L2; PD-L2; PD1L2_HUMAN; B7 dendritic cell molecule; B7-DC; B7DC; bA574F11.2; Btdc; Butyrophilin B7 DC; Butyrophilin B7-DC; Butyrophilin B7DC; CD 273; CD273; CD273 antigen; MGC142238; MGC142240; PD 1 ligand 2; PD-1 ligand 2; PD1 ligand 2; PDCD 1 ligand

Cat:

SLM30107M

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human CD273 (B7-DC)

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

Mouse IgG1

Applications：

IHC-P=1:20-200IHC-F=1:20-200Flow-Cyt=ICC=1:20-200IF=1:20-200（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

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Unit:

Price: $376.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Involved in negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; and negative regulation of interleukin-10 production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Nov 2021]

Function:
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).

Subunit:
Interacts with PDCD1.

Subcellular Location:
Isoform 3: Secreted (Probable).
Isoform 2: Endomembrane system; Single-pass type I membrane protein.
Isoform 1: Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.

Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.

SWISS:
Q9BQ51

Gene ID:
80380

Database links:

Entrez Gene: 80380 Human

Omim: 605723 Human

SwissProt: Q9BQ51 Human

Unigene: 532279 Human

Unigene: 617872 Human

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