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Mouse Anti-Cyclin A2 antibody
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008].
Function:
Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
Subunit:
Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER.
Subcellular Location:
Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER.
Post-translational modifications:
Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
Similarity:
Belongs to the cyclin family. Cyclin AB subfamily.
SWISS:
P51943
Gene ID:
890
Database links:
Entrez Gene: 890 Human
Entrez Gene: 12428 Mouse
Entrez Gene: 114494 Rat
Omim: 123835 Human
SwissProt: P20248 Human
SwissProt: P51943 Mouse
Unigene: 58974 Human
Unigene: 4189 Mouse
Unigene: 13094 Rat
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