The protein encoded by this gene is a member of the S100family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are localized in the cytoplasm and/or nucleus of awide range of cells, and involved in the regulation of a number ofcellular processes such as cell cycle progression anddifferentiation. S100 genes include at least 13 members which arelocated as a cluster on chromosome 1q21. This protein may have atumor suppressor function. Chromosomal rearrangements and alteredexpression of this gene have been implicated in breast cancer.
Function:
May act as a modulator against excess calciumaccumulation in normal human mammary epithelial cells. May alsoplay a role in suppressing tumor cell growth.
Subunit:
Homodimer. Interacts with FKBP4.
Tissue Specificity:
A subset of epithelial cells including normalhuman mammary epithelial cells and keratinocytes.
Similarity:
Belongs to the S-100 family
Contains 2 EF-hand domains.
SWISS:
P29034
Gene ID:
6273
Database links:
Entrez Gene: 6273 Human
Entrez Gene: 628324 Mouse
Omim: 176993 Human
SwissProt: P29034 Human
Unigene: 516484 Human
Unigene: 489562 Mouse
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