MAPK15 is a 544 amino acid protein that belongs to the CMGC Ser/Thr protein kinase family (MAP kinase subfamily). MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPK15 functions as a catalytic kinase using ATP to produce ADP and a phosphoprotein. A TXY motif, containing one threonine and one tyrosine residue, activates the MAP kinases upon phosphorylation. MAPK15 is a ubiquitously expressed protein with highest expression found in lung and kidney.
Function:
In vitro, phosphorylates MBP.
Tissue Specificity:
Widely expressed with a maximal expression in lung and kidney.
Post-translational modifications:
Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro.
Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase.
Similarity:
Belongs to the protein kinase superfamily.
CMGC Ser/Thr protein kinase family.
MAP kinase subfamily.
Contains 1 protein kinase domain.
SWISS:
Q8TD08
Gene ID:
225689
Database links:
Entrez Gene: 225689 Human
SwissProt: Q8TD08 Human
Unigene: 493169 Human
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