background:
G protein-coupled receptors (GPRs or GPCRs), also known as seven transmembrane receptors, heptahelical receptors, or 7TM receptors, are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR proteins are integral seven-pass membrane proteins with some conserved amino acid regions. G-protein coupled receptor 10 (GPR10) acts as a receptor for prolactin-releasing peptide (PrRP). GPR10 plays a role in the regulation of food intake, pain-signal processing and lactation. Primarily expressed in pituitary gland, it is repressed by bromocriptine. GPR10 interacts with various other proteins, including GRIP1, GRIP2 and PICK1.
Function:
Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.
Subunit:
Interacts through its SLCterminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Only detected in the pituitary gland and in all cell types of pituitary adenomas.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 510397 Cow
Entrez Gene: 486911 Dog
Entrez Gene: 2834 Human
Entrez Gene: 100412185 Marmoset (common)
Entrez Gene: 226278 Mouse
Entrez Gene: 100523144 Pig
Entrez Gene: 29275 Rat
Omim: 600895 Human
SwissProt: Q4EW11 Cow
SwissProt: P49683 Human
SwissProt: Q6VMN6 Mouse
SwissProt: Q64121 Rat
Unigene: 248119 Human
Unigene: 377241 Mouse
Unigene: 138127 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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