Home
>
Product
>
Antibody
>
Rabbit Anti-C1D/FITC Conjugated antibody
background:
C1D, also known as SUNCOR, is a nuclear DNA-binding protein that localizes to the nucleus and cytoplasm and participates in processing of the 5.8S rRNA. Expressed ubiquitously with highest expression in thyroid, salivary gland, hippocampus and medulla oblongata, C1D forms a multi-protein complex with MPP6 (M phase phosphoprotein 6) and EXOSC10 (exosome component 10). This complex is responsible, in part, for recruiting the exosome to pre-rRNA and it functions to mediate 3’-5’ rRNA processing. Additionally, C1D can induce transcriptional repression and apoptosis through interaction with Rev-erbα (SLVerbA-related protein EAR-1)/TRβ (thyroid hormone receptor β) and p53, respectively. C1D, a 141 amino acid protein, is also implicated in DNA repair mechanisms, as well as DNA-PK (DNA-dependent protein kinase) activation.
Function:
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB.
Subcellular Location:
Cytoplasm. Nucleus > nucleolus. EXOSC10 is required for nucleolar localization.
Tissue Specificity:
Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon.
Post-translational modifications:
Phosphorylated by PRKDC.
Similarity:
Belongs to the C1D family.
Database links:
Entrez Gene: 10438 Human
Entrez Gene: 506667 Cow
Entrez Gene: 57316 Mouse
Entrez Gene: 289810 Rat
Omim: 606997 Human
SwissProt: Q32PE4 Cow
SwissProt: Q13901 Human
SwissProt: O35473 Mouse
Unigene: 87882 Cow
Unigene: 60580 Human
Unigene: 697447 Human
Unigene: 287982 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|