Rabbit Anti-COPZ1/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-COPZ1/FITC Conjugated antibody

5930435A22Rik; AA407760; CGI 120; Coatomer protein complex subunit zeta 1; Coatomer subunit zeta 1; Coatomer subunit zeta-1; COPZ; COPZ 1; COPZ1; COPZ1_HUMAN; D4Ertd360e; HSPC181; MGC118060; Zeta 1 coat protein; zeta 1 COP; zeta COP; Zeta-

Cat:

SL13982R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human COPZ1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

20kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

Subcellular Location:
Cytoplasm. Golgi apparatus membrane. Cytoplasmic vesicle > COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the adaptor complexes small subunit family.

Database links:

Entrez Gene: 22818 Human

Entrez Gene: 281707 Cow

Entrez Gene: 56447 Mouse

SwissProt: P35604 Cow

SwissProt: P61923 Human

SwissProt: P61924 Mouse

Unigene: 43744 Cow

Unigene: 505652 Human

Unigene: 29473 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall