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Rabbit Anti-COQ3/FITC Conjugated antibody
background:
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]
Function:
COQ3 (Coenzyme Q3 homolog, methyltransferase) is an O-methyltransferase essential in the biosynthetic pathway of coenzyme Q (ubiquinone).
Subcellular Location:
Mitochondrion matrix.
Similarity:
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Database links:
Entrez Gene: 5365 Human
Omim: 605196 Human
SwissProt: Q9NZJ6 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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