Home
>
Product
>
Antibody
>
Rabbit Anti-CPAMD8/FITC Conjugated antibody
background:
CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]).[supplied by OMIM, Mar 2008]
Function:
Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine.
Subcellular Location:
Secreted. Cell membrane.
Post-translational modifications:
Proteolytically cleaved into 2 chains of about 70 and 130 kDa. The fragments are not connected by disulfide bonds.
Similarity:
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Contains 1 Kazal-like domain.
Database links:
Entrez Gene: 27151 Human
Omim: 608841 Human
SwissProt: Q8IZJ3 Human
Unigene: 631644 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|