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Rabbit Anti-CRISP11/FITC Conjugated antibody
background:
Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins that may play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. CRISP proteins are highly expressed in the mammalian reproductive tract and in the venom secretory ducts of some reptiles. CRISP-11 (cysteine-rich secretory protein 11), also known as cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2 or LCRISP2), is a 497 amino acid protein containing 2 LCCL domains, which are thought to function as autonomous folding domains used to construct modular proteins through exon shuffling. Serum concentrations of CRISP-11 have been shown to be an indicator of a patient’s exposure to lipopolysaccahride (LPS), the immunostimulatory component of Gram-negative bacteria, and can determine one’s sensitivity to it.
Function:
Promotes matrix assembly.
Subcellular Location:
Secreted.
Similarity:
Belongs to the CRISP family.
Contains 2 LCCL domains.
Database links:
Entrez Gene: 83716 Human
Entrez Gene: 78892 Mouse
Entrez Gene: 171547 Rat
Omim: 612434 Human
SwissProt: Q9H0B8 Human
SwissProt: Q8BZQ2 Mouse
Unigene: 513779 Human
Unigene: 617091 Human
Unigene: 264136 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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