background:
Idax is a 198 amino acid cytoplasmic protein that functions as a negative regulator of the Wnt signaling pathway through its interaction with the PDZ domain of Dvl-1. Containing one CXXSLCtype zinc finger, Idax is expressed at high levels in brain, with lower levels in testis and thymus. The gene encoding Idax maps to human chromosome 4, which represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Function:
Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.
Subcellular Location:
Cytoplasm.
Similarity:
Contains 1 CXXSLCtype zinc finger.
Database links:
Entrez Gene: 80319 Human
Entrez Gene: 319478 Mouse
Entrez Gene: 83824 Rat
SwissProt: Q9H2H0 Human
SwissProt: Q6NXI8 Mouse
SwissProt: Q9EQC9 Rat
Unigene: 12248 Human
Unigene: 224814 Mouse
Unigene: 442744 Mouse
Unigene: 457442 Mouse
Unigene: 209562 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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