Rabbit Anti-DCUN1D1/FITC Conjugated antibody

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DCN1 defective in cullin neddylation 1 domain containing 1; DCN1 like protein 1; DCNL1; DCNL1_HUMAN; DCUN1 domain containing protein 1; DCUN1L1; Defective in cullin neddylation protein 1 like protein 1; RP 42; RP42; RP42 homolog; SCCRO; SCRO; S

Cat:

SL14306R-FITC

Species Reactivity：

Mouse,(predicted: Human,Chicken,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human DCUN1D1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

30kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
DCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.

Database links:

Entrez Gene: 54165 Human

Entrez Gene: 424963 Chicken

Entrez Gene: 539869 Cow

Entrez Gene: 114893 Mouse

Entrez Gene: 327232 Zebrafish

Omim: 605905 Human

SwissProt: Q5ZKU1 Chicken

SwissProt: Q96GG9 Human

SwissProt: Q9QZ73 Mouse

Unigene: 104613 Human

Unigene: 374810 Mouse

Unigene: 379305 Mouse

Unigene: 474495 Mouse

Unigene: 22807 Zebrafish

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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