background:
Dcun1D3 is a 304 amino acid protein that contains one Dcun1 domain. The Dcun1 domain is an approximately 190 residue module that is thought to have the features of a basic helix-loop-helix leucine zipper domain, a domain commonly found in transcription factors. It has been suggested that Dcun1D3 may be involved in cell cycle progression and cell growth. The gene that encodes Dcun1D3 maps to human chromosome 16, which encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. Chromosome 16 houses the CREBBP gene that encodes a critical CREB binding protein that is responsible for the Rubinstein-Taybi syndrome, a rare disorder characterized by mental retardation and predisposition to tumor growth and white blood cell neoplasias.
Subcellular Location:
Contains 1 DCUN1 domain.
Database links:
Entrez Gene: 123879 Human
Entrez Gene: 504926 Cow
Entrez Gene: 233805 Mouse
Entrez Gene: 309035 Rat
SwissProt: Q5E9V1 Cow
SwissProt: Q8IWE4 Human
SwissProt: Q8K0V2 Mouse
SwissProt: Q4V8B2 Rat
Unigene: 101007 Human
Unigene: 31539 Mouse
Unigene: 211721 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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