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Rabbit Anti-S100A11/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq]
Function:
Facilitates the differentiation and the cornification of keratinocytes.
Subunit:
Homodimer; disulfide-linked.
Subcellular Location:
Cytoplasm. Nucleus.
Post-translational modifications:
Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.
Similarity:
Belongs to the S-100 family.
Contains 2 EF-hand domains.
Database links:
Entrez Gene: 6282 Human
Omim: 603114 Human
SwissProt: P31949 Human
Unigene: 417004 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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