Rabbit Anti-DDOST/FITC Conjugated antibody

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Advanced glycation endproduct receptor 1; AGE R1; AGER1; CDG1R; DDOST 48 kDa subunit; Dolichyl diphosphooligosaccharide protein glycosyltransferase subunit (non catalytic); Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subuni

Cat:

SL14213R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Cow,Horse,Zebrafish,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human DDOST/AGER1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

43kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]

Function:
DDOST (Dolichyl-diphosphooligosaccharide-protein glycosyltransferase) is a component of the oligosaccharyltransferase complex. This complex catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum and co-purifies with ribosomes. DDOST is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.

Subunit:
Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes even after release from the ribosome.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Database links.

DISEASE:
Congenital disorder of glycosylation 1R (CDG1R) [MIM:614507]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the DDOST 48 kDa subunit family.

Database links:

Entrez Gene: 1650 Human

Entrez Gene: 425542 Chicken

Entrez Gene: 510682 Cow

Entrez Gene: 404012 Dog

Entrez Gene: 1640 Mouse

Entrez Gene: 313648 Rat

Entrez Gene: 444283 Xenopus laevis

Entrez Gene: 100145597 Xenopus tropicalis

Entrez Gene: 401288 Zebrafish

Omim: 602202 Human

SwissProt: P4888 Chicken

SwissProt: A6QPY0 Cow