Rabbit Anti-Deltex/FITC Conjugated antibody

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Deltex homolog 1 (Drosophila); Deltex protein 1; Deltex-1; Deltex1; Dtx1; E3 ubiquitin protein ligase DTX1; FXI-T1; Fxit 1; Fxit1; DTX1_HUMAN; hDTX1; hDx 1; mDTX1; Protein deltex 1.

Cat:

SL14265R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Deltex

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

67kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

Function:
Deltex is a RING finger ubiquitin ligase which is conserved from Drosophila to Humans and is a regulator of Notch signaling pathway. Deltex regulates both B-cell lineage and splenic marginal-zone B-cell commitment. Deltex is implicated in neurogenesis, lymphogenesis and myogenesis as well as marginal zone B cell differentiation.

Subunit:
Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 via its N-terminus region and EIF3F, the interaction is required for NOTCH1 deubiquitination. Interacts with EP300. Forms a heterodimer with BBAP; the heterodimerization leading to an increase of in vitro ubiquitin ligase activity. Interacts with ITCH.

Subcellular Location:
Cytoplasm and Nucleus. Note: Predominantly cytoplasmic, partially nuclear.

Tissue Specificity:
Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.

Post-translational modifications:
Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.

Similarity:
Belongs to the Deltex family.
Contains 1 RING-type zinc finger.
Contains 2 WWE domains.

Database links:

Entrez Gene: 1168 Human

Entrez Gene: 14357 Mouse

Omim: 602582 Human

SwissProt: Q86Y01 Human

SwissProt: Q61010 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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