background:
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
Function:
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.
Subcellular Location:
Cytoplasm. Nucleus. Cell membrane.
Tissue Specificity:
Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.
Post-translational modifications:
Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.
Similarity:
Belongs to the eukaryotic diacylglycerol kinase family.
Contains 2 ANK repeats.
Contains 1 DAGKc domain.
Contains 2 phorbol-ester/DAG-type zinc fingers.
Database links:
Entrez Gene: 8525 Human
Entrez Gene: 423197 Chicken
Entrez Gene: 483635 Dog
Entrez Gene: 100050499 Horse
Entrez Gene: 104418 Mouse
Entrez Gene: 81821 Rat
Omim: 601441 Human
SwissProt: Q13574 Human
SwissProt: Q80UP3 Mouse
SwissProt: O08560 Rat
Unigene: 502461 Human
Unigene: 314923 Mouse
Unigene: 11208 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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