background:
This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]
Function:
DIP2 homolog B, elongs to the DIP2 family. It is moderately expressed in adult brain, placenta, skeletal muscle, heart, kidney, pancreas, lung, spleen and colon. There are two isoforms produced by alternative splicing.
Subcellular Location:
Nucleus
Similarity:
Belongs to the DIP2 family.
Database links:
Entrez Gene: 57609 Human
Entrez Gene: 239667 Mouse
Entrez Gene: 300231 Rat
Omim: 611379 Human
SwissProt: Q9P265 Human
SwissProt: Q3UH60 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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