Rabbit Anti-NALP6/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-NALP6/FITC Conjugated antibody

CLR11.4; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD containing protein 6; NACHT, LRR and PYD domains-containing protein 6; NALP6_HUMAN; NLR family, pyrin domain containing 6; Nlrp6; Nucleotide binding oligomerization domain, leuci

Cat:

SL1088R-FITC

Species Reactivity：

Mouse,Rat,(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human NALP6

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

37kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a SLCterminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a SLCterminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Function:
May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Isoform 1 binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Isoform 2 binds both arginine-vasopressin and angiotensin II and acts as an angiotensin II/vasopressin receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation.

Subunit:
Binds to ASC with its DAPIN domain.

Subcellular Location:
Isoform 1: Cytoplasm. Cell membrane. Nucleus membrane. Isoform 2: Cytoplasm. Cell membrane. Note=Predominantly expressed in the cell membrane.

Tissue Specificity:
Highly expressed in the small and large intestine, kidney and liver.

Similarity:
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 3 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.

Database links:

Entrez Gene: 171389 Human

Omim: 609650 Human

SwissProt: P59044 Human

Unigene: 352611 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall