Home
>
Product
>
Antibody
>
Rabbit Anti-DIXDC1/FITC Conjugated antibody
background:
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Function:
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
Subcellular Location:
Cytoplasm; Cell junction; focal adhesion. Associated with actin stress fiber at the filament ends and Cytoplasm; cytosol. Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis.
Tissue Specificity:
Ubiquitously expressed with higher expression in cardiac and skeletal muscles.
Post-translational modifications:
Phosphorylated on tyrosine and serine residues.
Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation.
Similarity:
Belongs to the DIXDC1 family.
Contains 1 CH (calponin-homology) domain.
Contains 1 DIX domain.
Database links:
Entrez Gene: 85458 Human
Omim: 610493 Human
SwissProt: Q155Q3 Human
Unigene: 655626 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|