Rabbit Anti-DLEC1/FITC Conjugated antibody

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Deleted in lung and esophageal cancer 1; Deleted in lung and esophageal cancer 1 transcript varient 2; Deleted in lung and esophageal cancer protein 1; Deleted in lung cancer protein 1; DLC 1; Dlc-1; DLC1; Dlec1; DLEC1_HUMAN; F56.

Cat:

SL14341R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human DLEC1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

196kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney. [provided by RefSeq, Jul 2008]

Function:
May act as a tumor suppressor by inhibiting cell proliferation.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in all tissues examined. Expression is highest in prostate and testis.

DISEASE:
Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal, renal and lung cancers.

Database links:

Entrez Gene: 9940 Human

Omim: 604050 Human

SwissProt: Q9Y238 Human

Unigene: 714499 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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