background:
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008]
Subcellular Location:
Nucleus.
DISEASE:
First expressed in embryos at 8.5-9 days in facial and branchial arch mesenchyme, otic vesicles and frontonasal ectoderm around olfactory placodes, a day later expression is seen in the developing forebrain in primordia of the ganglionic eminence and ventral diencephalic regions. In day 12.5 embryos, expressed in the brain and bones, and also in all skeletal structures of midgestation embryos after the first cartilage formation, and expression progressively declines in both brain and skeleton in day 15 embryos.
Similarity:
Belongs to the distal-less homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:
Entrez Gene: 1750 Human
Entrez Gene: 13396 Mouse
Entrez Gene: 500023 Rat
Entrez Gene: 30586 Zebrafish
Omim: 600030 Human
SwissProt: P56179 Human
SwissProt: P70397 Mouse
SwissProt: Q98877 Zebrafish
Unigene: 249196 Human
Unigene: 439763 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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