background:
The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]
Function:
Expressed in testis, kidney and skeletal muscle.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the DMRT family.
Contains 1 DM DNA-binding domain.
Database links:
Entrez Gene: 10655 Human
Entrez Gene: 226049 Mouse
Omim: 604935 Human
SwissProt: B1ANC0 Human
SwissProt: Q9Y5R5 Human
SwissProt: Q3USI4 Mouse
SwissProt: Q3USI7 Mouse
SwissProt: Q8BG36 Mouse
SwissProt: Q8K185 Mouse
Unigene: 59506 Human
Unigene: 11448 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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