background:
Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; complexes that transport cellular cargo toward the central region of the cell. Axonemal dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH12 is a 3,092 amino acid protein of cilium axoneme that exists as three alternatively spliced isoforms. A member of the dynein heavy chain family, DNAH12L is involved in sperm flagellar assembly and is encoded by a gene located on human chromosome 3.
Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly
Subunit:
Consists of at least two heavy chains and a number of intermediate and light chains.
Subcellular Location:
Cytoplasm, cytoskeleton, cilium axoneme.
Similarity:
Belongs to the dynein heavy chain family.
Database links:
Entrez Gene: 201625 Human
SwissProt: Q6ZR08 Human
Unigene: 201378 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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