Rabbit Anti-VEGF-D/FITC Conjugated antibody

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Vascular Endothelial Growth Factor D; VEGFD; VEGF D; FIGF; VEGFD_HUMAN; VEGF-D; c-Fos-induced growth factor.

Cat:

SL10259R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human VEGF-D

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

39kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011].

Function:
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (Flk1) and VEGFR-3 (Flt4) receptors. [SUBUNIT] Homodimer; non-covalent and antiparallel.

Subunit:
Homodimer; non-covalent and antiparallel.

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.

Post-translational modifications:
Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.

Similarity:
Belongs to the PDGF/VEGF growth factor family.

Database links:

Entrez Gene: 2277 Human

Entrez Gene: 14205 Mouse

Entrez Gene: 72457 Rat

Omim: 300091 Human

SwissProt: O43915 Human

SwissProt: P97946 Mouse

SwissProt: O35251 Rat

Unigene: 11392 Human

Unigene: 297978 Mouse

Unigene: 10796 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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