Rabbit Anti-DNASE2B/FITC Conjugated antibody

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Deoxyribonuclease 2 beta; Deoxyribonuclease 2 beta precursor; Deoxyribonuclease II beta; DLAD; DNase 2 like acid DNase; DNASE 2B; DNase II beta; DNase II like acid DNase; DNASE2; DNase2 like acid DNase; DnaseIIb; DNS2B_HUMAN; EC 3.1.22.1; Endo

Cat:

SL14396R-FITC

Species Reactivity：

(predicted: Human,Mouse,Pig,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human DNASE2B

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

39kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Function:
DNASE2B shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this protein is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.

Subcellular Location:
Lysosome

Similarity:
Belongs to the DNase II family.

Database links:

Entrez Gene: 58511 Human

Omim: 608057 Human

SwissProt: Q8WZ79 Human

Unigene: 129142 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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