background:
Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.
Function:
Transcriptional transactivator. Binds double stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.
Subunit:
Forms a complex with E6-AP ubiquitin-protein ligase which interacts with human P53. Binds to human FBLN1, MAGI3 and MPDZ.
Subcellular Location:
Host nucleus matrix (By similarity).
Similarity:
Belongs to the papillomaviridae E6 protein family.
Database links:
Entrez Gene: 1489088 HPV18 E6
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
人类乳头状瘤病毒18（HPV18-E6）是导致女性宫颈癌的主要病毒型（包括人类乳头状瘤病毒16）
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