Mouse Anti-CRIPTO/FITC Conjugated antibody

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CRIPTO; CRIPT; CR; CRGF; Cripto 1; Cripto-1; Cripto 1 growth factor; Cripto-1 growth factor; Cripto1; Cripto1 growth factor; Epidermal growth factor like cripto protein CR1; Epidermal growth factor-like cripto protein CR1; TDGF 1; TDGF-1; TDGF1; Teratocar

Cat:

SLM2313M-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human Teratocarcinoma-derived growth factor 1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

Calculated MW：

13kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].

Function:
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

Subunit:
Interacts with the activin type-1 receptor ACVR1B.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Similarity:
Contains 1 EGF-like domain.

Database links:

Entrez Gene: 716829 Cow

Entrez Gene: 6997 Human

Entrez Gene: 21667 Mouse

Omim: 187395 Human

SwissProt: P13385 Human

SwissProt: P51865 Mouse

Unigene: 385870 Human

Unigene: 5090 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cripto-1是表皮生长因子-Cripto-FRL-Criptic(EGF-CFC)家族成员之一, 属于转化生长细胞TGF-β蛋白家族及Nodal蛋白质的共同受体。Cripto蛋白对于胚胎的发育占有非常重要的地位。 Cripto-1在人类的多种肿瘤如结肠癌、乳腺癌、卵巢癌、胰腺癌等中高表达，可激活P13K/Akt/GSK-3βc-Src和ras/raf/MAPK信号通路,介导细胞增殖和抑制细胞凋亡，Cripto蛋白的单细胞繁殖抗体，可以有效抑制一些癌细胞的生长。

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