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Mouse Anti-Aquaporin 4 /FITC Conjugated antibody
background:
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
Subunit:
Homotetramer. Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Brain, muscle, heart, kidney, lung, and trachea.
Similarity:
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Database links:
Entrez Gene: 281008 Cow
Entrez Gene: 361 Human
Entrez Gene: 11829 Mouse
Entrez Gene: 25293 Rat
Omim: 600308 Human
SwissProt: O77750 Cow
SwissProt: P55087 Human
SwissProt: P55088 Mouse
SwissProt: P47863 Rat
Unigene: 281008 Cow
Unigene: 315369 Human
Unigene: 250786 Mouse
Unigene: 90091 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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