Mouse Anti-CD23/FITC Conjugated antibody

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Fc EpsilonR II; FcεRII; Blast 2; Blast2; C type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD 23; CD 23A; CD23 antigen; CD23A; CLEC 4J; CLEC4J; Fc epsilon RII; Fc fragment of IgE low affinity II receptor for; Fc fragment of

Cat:

SLM33088M-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,)

Immunogen：

Recombinant human CD23

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

Calculated MW：

36kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a “membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

Function:
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Subcellular Location:
Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form.

Post-translational modifications:
N- and O-glycosylated.

Similarity:
Contains 1 SLCtype lectin domain.

Database links:

Entrez Gene: 2208 Human

Entrez Gene: 14128 Mouse

Omim: 151445 Human

SwissProt: P06734 Human

SwissProt: P20693 Mouse

Unigene: 465778 Human

Unigene: 1233 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD23是一种II型跨膜糖蛋白，是存在于B细胞表面的IgE受体。在慢性B淋巴细胞白血病（CLL）和小B细胞淋巴瘤（SLL）为阳性，套细胞淋巴瘤和小核裂淋巴细胞淋巴瘤阴性。也表达于外周血B细胞的某些亚型、B淋巴细胞和EB病毒转染的B淋巴瘤细胞系。CD23是慢性B淋巴细胞白血病，小B细胞淋巴瘤诊断和鉴别诊断有用的标记物。

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