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Mouse Anti-CD20/FITC Conjugated antibody
background:
CD20 is a non glycosylated protein with a molecular weight of 35 or 37 kDa depending on the degree of phosphorylation. Although not a member of the tetraspanin superfamily of cell surface receptors, it crosses the cell membrane four times. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit.
Function:
This protein may be involved in the regulation of B-cell activation and proliferation
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed on B-cells.
Post-translational modifications:
Phosphorylated. Might be functionally regulated by protein kinase(s).
DISEASE:
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Similarity:
Belongs to the MS4A family.
Database links:
Entrez Gene: 931 Human
Omim: 112210 Human
SwissProt: P11836 Human
Unigene: 712553 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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