background:
Myostatin (GDF8)is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology.
Function:
Acts specifically as a negative regulator of skeletal muscle growth.
Subunit:
Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3.
Subcellular Location:
Secreted.
Tissue Specificity:
Predominantly expressed in muscle. At hatching, expression is strongest in the skin epithelium, and is also found in the retina and brain. From day 28, expressed in skeletal muscle. In the adult, highest expression is seen in the gastrointestinal tract, brain, muscle, heart and testis. Also expressed in the adult pharynx, kidney, spleen, liver, gill, eyes, skin, swim bladder and ovary.
DISEASE:
Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong.
Similarity:
Belongs to the TGF-beta family.
Database links:
Entrez Gene: 2660 Human
Entrez Gene: 17700 Mouse
Entrez Gene: 373964 Chicken
Entrez Gene: 399534 Pig
Entrez Gene: 29152 Rat
Entrez Gene: 798441 Zebrafish
Omim: 601788 Human
SwissProt: O14793 Human
SwissProt: O08689 Mouse
SwissProt: O35312 Rat
SwissProt: O18830 Sheep
SwissProt: O42222 Zebrafish
Unigene: 41565 Human
Unigene: 3514 Mouse
Unigene: 4492 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GDF-8又称MSTN,是转化生长因子超家族，也是近年来发现的一类重要的肌细胞生长调控因子，它通过抑制MyoD家族成员转录活性负向控制肌细胞的生长发育，它的表达量与肌肉重量的变化呈负相关。
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