background:
Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B-cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.
Subcellular Location:
Secreted.
Database links:
Entrez Gene: 3493?/span>Human
Entrez Gene: 3494?/span>Human
Omim: 146900?/span>Human
Omim: 147000?/span>Human
SwissProt: P01876?/span>Human
SwissProt: P01877?/span>Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|