Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Function:
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Subunit:
Binds the type 2 receptor protein ACVR2A (By similarity).
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
SWISS:
Q8NER5
Gene ID:
130399
Database links:
Entrez Gene: 130399 Human
Entrez Gene: 269275 Mouse
Entrez Gene: 245921 Rat
Omim: 608981 Human
SwissProt: Q8NER5 Human
SwissProt: Q8K348 Mouse
SwissProt: P70539 Rat
Unigene: 562901 Human
Unigene: 77751 Mouse
Unigene: 10580 Rat
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Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-Activin A Receptor Type IC (SL5777R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 53 kD
Sample:
HepG2(Human) Cell Lysate at 30 ug
Hela(Human) Cell Lysate at 30 ug
Primary: Anti-Activin A Receptor Type IC (SL5777R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 53 kD
Sample:
Placenta (Mouse) Lysate at 40 ug
Primary: Anti-Activin A Receptor Type IC (SL5777R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 53 kD
Blank control: H9C2 (blue)
Isotype Control Antibody: Rabbit IgG(orange) ;
Secondary Antibody: Goat anti-rabbit IgG-FITC(white blue),
Dilution: 1:100 in 1 X PBS containing 0.5% BSA ;
Primary Antibody Dilution: 3μl in 100 μL1X PBS containing 0.5% BSA(green).
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