Rabbit Anti-Nectin 4 antibody

Home > Product > Antibody > Rabbit Anti-Nectin 4 antibody

Ig superfamily receptor LNIR; Nectin 4; poliovirus receptor-related 4; PRR4; poliovirus receptor related 4; DKFZp686K05193; EDSS1; Nectin-4; poliovirus receptor-related 4; Processed poliovirus receptor-related protein 4; pvrl4; PVRL4_HUMAN.

Cat:

SL10029R

Species Reactivity：

Human,Mouse,(predicted: Rat,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Nectin 4:151-250/510

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Skin (Mouse) Lysate at 40 ugPrimary: Anti-Nectin 4 (SL10029R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 53 kDObserved band size: 53 kDSample: MCF-7(Human) Cell Lysate at 30 ugPrimary: Anti- Nectin 4 (SL10029R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 53 kDObserved band size: 55 kDSample: A431(Human) Cell Lysate at 30 ugThymus (Mouse) Lysate at 40 ugPrimary: Anti- Nectin 4 (SL10029R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 53 kDObserved band size: 55 kDSample: MCF-7 Cell (Human) Lysate at 30 ugPrimary: Anti-Nectin 4 (SL 10029R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 53 kDObserved band size: 53 kD

prev next

Unit:

Price: $220.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like SLVtype domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Function:
Self-associates. Interacts via its Ig-like SLVtype domain with PVRL1/nectin-1 Ig-like SLVtype domain. Interacts via its SLCterminus with MLLT4. Binds to Measles virus protein H and acts as a receptor for this virus.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, adherens junction. Processed poliovirus receptor-related protein 4: Secreted.

Tissue Specificity:
Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.

Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.

SWISS:
Q96NY8

Gene ID:
81607

Database links:

Entrez Gene: 81607 Human

Entrez Gene: 71740 Mouse

Entrez Gene: 498281 Rat

Omim: 609607 Human

SwissProt: Q5E9Z9 Cow

SwissProt: Q96NY8 Human

SwissProt: Q8R007 Mouse

Unigene: 492490 Human

Picture

Sample:
MCF-7(Human) Cell Lysate at 30 ug
Primary: Anti- Nectin 4 (SL10029R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 55 kD

Sample:
A431(Human) Cell Lysate at 30 ug
Thymus (Mouse) Lysate at 40 ug
Primary: Anti- Nectin 4 (SL10029R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 55 kD

Sample:
MCF-7 Cell (Human) Lysate at 30 ug
Primary: Anti-Nectin 4 (SL 10029R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 53 kD

Product Feedback Wall