KLH conjugated synthetic peptide derived from human 5HT2A Receptor:51-150/471<Extracellular>
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample: Small intestine (Mouse) Lysate at 40 ugPrimary: Anti-5HT2A Receptor (SL12049R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 53 kDObserved band size: 53 kDSample:Cerebellum (Mouse) Lysate at 40 ugPrimary: Anti-5HT2A Receptor (SL12049R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 53 kDObserved band size: 53 kDSample: Lane 1: Cerebrum (Mouse) Lysate at 40 ugLane 2: Cerebrum (Rat) Lysate at 40 ugPrimary: Anti-5HT2A Receptor (SL12049R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 53 kDObserved band size: 50 kD
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.
Subunit: Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2.
Subcellular Location: Cell membrane. Localizes to the post-synaptic thickening of axo-dendritic synapses.
Similarity: Belongs to the G-protein coupled receptor 1 family.
Sample: Small intestine (Mouse) Lysate at 40 ug
Primary: Anti-5HT2A Receptor (SL12049R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 53 kD
Sample:Cerebellum (Mouse) Lysate at 40 ug
Primary: Anti-5HT2A Receptor (SL12049R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 53 kD
Sample:
Lane 1: Cerebrum (Mouse) Lysate at 40 ug
Lane 2: Cerebrum (Rat) Lysate at 40 ug
Primary: Anti-5HT2A Receptor (SL12049R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 50 kD
Product Feedback Wall
Specific References (1) | SL12049R has been referenced in 1 publications.
[IF=3.395] Yue-Xin Li. et al. Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress:. Mol Pain. 0;(): WB ; Rat.
