This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Function:
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Subunit:
Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation
Subcellular Location:
Cytoplasmic and Nuclear
Tissue Specificity:
Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 CNH domain.
Contains 1 protein kinase domain.
SWISS:
Q8IVH8
Gene ID:
8491
Database links:
Entrez Gene: 8491 Human
Entrez Gene: 225028 Mouse
Entrez Gene: 170920 Rat
Omim: 604921 Human
SwissProt: Q8IVH8 Human
SwissProt: Q99JP0 Mouse
SwissProt: Q924I2 Rat
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