CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded SLCtype lectin-like receptors (Spreu et al., 2007 [PubMed 3646548]).[supplied by OMIM, May 2008]
Function:
Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B lymphocytes and naive CD4(+) T cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.
Post-translational modifications:
N-glycosylated.
Similarity:
Contains 1 SLCtype lectin domain.
SWISS:
Q6UVW9
Gene ID:
387836
Database links:
Entrez Gene: 387836 Human
Omim: 612087 Human
SwissProt: Q6UVW9 Human
Unigene: 1087866 Human
Unigene: 527665 Human
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