The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]
Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
Subunit:
Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPSLV16, HPSLV6B and HPSLV11.
Subcellular Location:
Membrane Curated; Multi-pass membrane protein; Cytoplasm; cytoskeleton; Nucleus
Similarity:
Belongs to the UBR4 family.
SWISS:
Q5T4S7
Gene ID:
23352
Database links:
HGNC: 30313
Entrez Gene: 23352
Ensembl: ENSG00000127481
OMIM: 609890
UniProtKB: Q5T4S7
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