This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]
Function:
GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology.
Subunit:
Interacts with the CRIB domains of proteins such as Pak1 and Was/Wasp.
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the small GTPase superfamily. Rho family.
SWISS:
Q9H4E5
Gene ID:
57381
Database links:
Entrez Gene: 57381 Human
Entrez Gene: 80837 Mouse
Entrez Gene: 299145 Rat
Omim: 607653 Human
SwissProt: Q9H4E5 Human
SwissProt: Q9ER71 Mouse
Unigene: 656339 Human
Unigene: 27467 Mouse
Unigene: 228606 Rat
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