Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Function:
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells.
Subunit:
Interacts with PCNA.
Subcellular Location:
Cytoplasm and Nucleus.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the poly(ADP-ribose) glycohydrolase family.
SWISS:
Q86W56
Gene ID:
8505
Database links:
Entrez Gene: 8505 Human
Entrez Gene: 26430 Mouse
Omim: 603501 Human
SwissProt: Q86W56 Human
SwissProt: O88622 Mouse
Unigene: 10136 Human
Unigene: 499594 Human
Unigene: 535298 Human
Unigene: 15962 Mouse
|
|
