RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.
Function:
Inhibits activation of NF-kappa-B mediated by TNF.
Subunit:
Binds TRAF1 and TRAF2 and is part of the receptor-TRAF signaling complex. Interacts with CYLD.
Subcellular Location:
Cytoplasm. Cytoplasm, perinuclear region.
Similarity:
Contains 1 RING-type zinc finger.
SWISS:
Q9BWF2
Gene ID:
10293
Database links:
Entrez Gene: 10293 Human
Omim: 605958 Human
SwissProt: Q9BWF2 Human
Unigene: 517972 Human
|
|