Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Function:
May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.
Subcellular Location:
Nucleus.Cytoplasm.
Tissue Specificity:
Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.
Post-translational modifications:
Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells.
Similarity:
Contains 1 PARP catalytic domain.
SWISS:
Q53GL7
Gene ID:
84875
Database links:
Entrez Gene: 84875 Human
Entrez Gene: 671535 Mouse
Entrez Gene: 100362108 Rat
Omim: 609564 Human
SwissProt: Q53GL7 Human
Unigene: 348609 Human
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