This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Function:
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.
Subunit:
Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin.
Subcellular Location:
Cell junction > focal adhesion. Cell membrane. Cytoplasm > cytoskeleton. Constituent of focal adhesions.
Tissue Specificity:
Expressed predominantly in heart and skeletal muscle.
Similarity:
Belongs to the parvin family.
Contains 2 CH (calponin-homology) domains.
SWISS:
Q9HBI1
Gene ID:
29780
Database links:
Entrez Gene: 29780 Human
Entrez Gene: 170736 Mouse
Entrez Gene: 362973 Rat
Omim: 608121 Human
SwissProt: Q9HBI1 Human
SwissProt: Q9ES46 Mouse
Unigene: 475074 Human
Unigene: 323892 Mouse
Unigene: 16709 Rat
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