RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).
Subunit:
Interacts (via region A) with DDX6/RCK. Interacts (via region H and region C) with LSM1 and LSM4. Interacts (via region N) with DCP1A, DCP2, EDC3, EDC4 and XRN1. Interacts with the CCR4-NOT complex. Interacts with the Lsm-containing SMN-Sm protein complex.
Subcellular Location:
Cytoplasm > P-body.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the PAT1 family.
SWISS:
Q86TB9
Gene ID:
219988
Database links:
Entrez Gene: 219988 Human
Entrez Gene: 225929 Mouse
SwissProt: Q86TB9 Human
SwissProt: Q3TC46 Mouse
Unigene: 591960 Human
Unigene: 42711 Mouse
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