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Rabbit Anti-PC5/PC6 antibody
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HISLV1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]
Function:
Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in T-lymphocytes.
Similarity:
Belongs to the peptidase S8 family.
Contains 1 homo B/P domain.
Contains 1 PLAC domain.
SWISS:
Q92824
Gene ID:
5125
Database links:
Entrez Gene: 5125 Human
Entrez Gene: 18552 Mouse
Entrez Gene: 116548 Rat
Omim: 600488 Human
SwissProt: Q92824 Human
SwissProt: Q04592 Mouse
SwissProt: P41413 Rat
Unigene: 368542 Human
Unigene: 3401 Mouse
Unigene: 104002 Rat
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