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Goat Anti-human IgA antibody
Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B-cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.
Subcellular Location:
Secreted.
SWISS:
P01876
Gene ID:
3493
Database links:
Entrez Gene: 3493 Human
Entrez Gene: 3494 Human
Omim: 146900 Human
Omim: 147000 Human
SwissProt: P01876 Human
SwissProt: P01877 Human
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