Interleukin-2; Interleukin 2; Interleukin2; T-cell growth factor; T Cell Growth Factor; Aldesleukin; IL 2; IL2; Lymphokine; POIL2; T Cell Growth Factor; TCGF; Involved in regulation of T cell clonal expansion; IL2_HUMAN.
Cat:
SLM0389M
Species Reactivity：
(predicted: Human,)
Immunogen：
Recombinant human IL-2:21-153/153
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Monoclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Subcellular Location: Secreted.
DISEASE: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Similarity: Belongs to the IL-2 family.
SWISS: P60568
Gene ID: 3558
Database links:
Entrez Gene: 3558 Human
Entrez Gene: 16183 Mouse
Entrez Gene: 116562 Rat
Omim: 147136 Human
SwissProt: P60568 Human
SwissProt: P04351 Mouse
SwissProt: P17108 Rat
Unigene: 89679 Human
Unigene: 14190 Mouse
Unigene: 9871 Rat
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Specific References (1) | SLM0389M has been referenced in 1 publications.
[IF=3.17] Zhang, Jia‐xiang, et al. "Complement C5a–C5aR interaction enhances MAPK signaling pathway activities to mediate renal injury in trichloroethylene sensitized BALB/c mice." Journal of Applied Toxicology (2015). IHSLCP ; Mouse.
