This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Function:
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
Subunit:
Interacts with the activin type-1 receptor ACVR1B.
Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity:
Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.
Similarity:
Contains 1 EGF-like domain.
SWISS:
P13385
Gene ID:
6997
Database links:
Entrez Gene: 716829 Cow
Entrez Gene: 6997 Human
Entrez Gene: 21667 Mouse
Omim: 187395 Human
SwissProt: P13385 Human
SwissProt: P51865 Mouse
Unigene: 385870 Human
Unigene: 5090 Mouse
Cripto-1是表皮生长因子-Cripto-FRL-Criptic(EGF-CFC)家族成员之一, 属于转化生长细胞TGF-β蛋白家族及Nodal蛋白质的共同受体。Cripto蛋白对于胚胎的发育占有非常重要的地位。 Cripto-1在人类的多种肿瘤如结肠癌、乳腺癌、卵巢癌、胰腺癌等中高表达，可激活P13K/Akt/GSK-3βc-Src和ras/raf/MAPK信号通路,介导细胞增殖和抑制细胞凋亡，Cripto蛋白的单细胞繁殖抗体，可以有效抑制一些癌细胞的生长。
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